Project Overview

The C3-Cloud project is a 4 year Horizon 2020 Research and Innovation Action project, under call PHC-25-2015 – advanced ICT systems and services for integrated care (total budget of 4,995,000 euros), that started in May 2016, run by a consortium of 12 partners across 7 countries in Europe.

C3-Cloud aims to develop personalised care plans for complex multimorbid patients, supported by ICT tools and managed by a coordinated multidisciplinary team, that promotes integrated care and the involvement of the patient and/or caregiver.

Tools and services

Decision support

Well aligned clinical guidelines that are better to use in combination for multimorbid patients, streamlined care pathways and optimised multimorbidity treatment options, including polypharmacy management. Read more

Personalised Care Plans

A multi-professional collaboration platform, making it easier to personalise a care plan to the needs of the patient so that clinicians and patients can follow it easily, and share the monitoring of progress towards agreed health and care goals. Read more

Patient Empowerment Platform

An app that patients can use to record their health status and track their own progress towards health goals. The use of this app leads to more active patient involvement and treatment adherence. Read more


To demonstrate feasibility, pilot studies focus on diabetes, heart failure, renal failure and depression in different comorbidity combinations. Pilots have been undertaken in 3 European regions with diverse health and social care systems and ICT landscape, which will allow for strengthening the evidence base on health outcomes and efficiency gains.

To date, 225 patients and several informal caregivers, 60 multidisciplinary healthcare professional teams have used the C3-Cloud solutions.

C3-Cloud adaptive patient pathways and organisational models validated by a clinical reference group, change management and training guidelines will be shared with the European community.

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under grant agreement No 689181.

Project Acronym

Project Name
A Federated Collaborative Care Cure Cloud Architecture for Addressing the Needs of Multimorbidity and Managing Polypharmacy

Funding Scheme
Horizon 2020 Research and Innovation Action

PHC-25-2015 – Advanced ICT systems and services for integrated care

4,995,000 EUR

May 2016 – August 2020


Quick links

Pilot Sites

The C3-Cloud solution is being piloted in 3 European regions in the UK, Spain and Sweden.  

South Warwickshire

South Warwickshire NHS Foundation Trust was formed in March 2010 and provides hospital services to South Warwickshire from four hospitals: Warwick Hospital, Leamington Spa Hospital, Stratford Hospital and Ellen Badger Hospital. The Trust employs 4,901 members of staff and delivers services to half a million people across Warwickshire. In addition Young People and Family services are provided in Coventry and Solihull.  The Trust also delivers out-of-hospital community services to the whole of Warwickshire serving a population of more than half a million from various clinics.

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Basque Country

Osakidetza is the public healthcare service of the Basque Country, a region located in the north of Spain.  More than 30,000 professionals work for Osakidetza, which could be considered the biggest organization of the Basque Country. Osakidetza has a target population of 2.17 million inhabitants, where in 2015 more than 20% of the total population was 65 or older. 100% of Basque population has been stratified since 2010.

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Region Jämtland Härjedalen

RJH’s legal status is a County Council. Its main responsibility is primary and secondary healthcare, as well as regional development in a region of approximately 130,000 inhabitants. RHJ also works with preventative measures and dentistry. Secondary healthcare is carried out at  Östersund Hospital – where there are 416 beds and 51 out-patient clinics. Primary healthcare is carried out in 28 locations in the sparsely-populated region, while home and social care are the responsibilities of its eight municipalities. There are roughly 4,000 employees in 100 different professions in RJH, and around 93% of the total budget is allocated to healthcare. As a relatively small but pro-active healthcare organisation, RJH has the experience and advantage of deploying and implementing eHealth innovations on a wide-scale.

Read more

Related Projects


1/1/2020 – 31/12/2023

ADLIFE aims to provide a solution to enhance quality of life, reduce suffering and accelerate recovery for patients with chronic diseases – including advanced severe life-threatening chronic diseases – and their families. The ADLIFE platform will deploy developed and validated personalised digital solutions for integrated supportive care based on H2020 projects C3-Cloud and Power2DM, previously tested in two health systems.

The ADLIFE Toolbox solutions include: a Personalised Care Plan Management Platform, Clinical Decision Support Services; Interoperability Solutions and Patient Empowerment Platform with Just-In Time Adaptive Intervention Delivery Engine.

MUrMUR project

2018 – 2023

HDR UK (Health Data Research UK) is the national institute for health data science, uniting the UK’s health data to enable discoveries that improve people’s lives. The Institute’s vision is that every health and care interaction and research endeavour will be enhanced by access to large scale data and advanced analytics. WARWICK is a member of the £30 million funded HDR UK project and Professor Theodoros Arvanitis is the Associate Director for the HDR UK Midlands Site.

The MUrMUR project works with researchers across the UK bringing together 6 different datasets, which hold anonymised information on over 10 million people, to explore multimorbidity in the UK at a scale never done before, i.e. to find out more about what diseases and conditions are found together, how they develop as people age and also which cause the most problems for people and the health service. This will allow researchers and health care workers to better plan how to deliver care to people with various types of multimorbidity. WARWICK, is participating in this project and pollinating ideas on multimorbidity, based on the experience of C3-Cloud.

EHR2EDC: From Electronic Health Records to Electronic Data Capture systems

1/1/2018 – 31/12/2019

This project is enabling the collection of clinical data from the electronic health records (EHRs) of several hospitals, to develop a system that can improve the efficiency of medical research, including research involving real world data. The EHR2EDC solution will enhance global research and accelerate access to treatment innovations.


1/10/2019 – 31/3/2023

HSMonitor is a H2020 pre-commercial procurement (PCP) 57 project looking for innovative monitoring solutions to improve health status and optimise hypertension care. Five healthcare providers from four countries (Turkey, Italy, Croatia and Sweden) are engaged in the procurement. The envisaged solutions should cover areas such as early detection and prevention, healthier lifestyle and nutrition, treatment adherence, training and education. Two C3-Cloud partners, RJH and empirica, are involved in HSMonitor and have contributed C3-Cloud‘s experience which led to informing the HSMonitor requirements for innovative solutions for hypertension care, with significant input to the requirements related to the development of shared care plans for patients with hypertension.

Digital Health Europe

1/1/2019 – 30/6/2021

DigitalHealthEurope is providing comprehensive, integrated and centralised support  to initiatives on digital health and care innovation in the context of the Digital Single Market Strategy. The project’s approach involves actions that will boost innovation and advance the three Digital Single Market priorities for the digital transformation of health and care.

Trillium II

1/1/2017 – 30/6/2019

International patient summary (IPS) standards consistently adapted and localized to serve the needs of specific use cases are essential to attaining of vision of the patient summary as a social good and human right. The Trillium Bridge project (2013-2015) compared patient summary standards and specification in Europe and the United states and demonstrated the technical feasibility of exchanging electronic health record summaries across the Atlantic in the context of emergency or unplanned care abroad.

Trillium II builds on the recommendations of Trillium Bridge and places IPS standards at the core of a global community for digital health innovation with the aim to advance patient safety & trust by bridging the gap between strategic intent and capability to deliver interoperability at a global scale.