SRDC team has strong expertise in e-health domain, and so far has developed several clinical decision support and chronic disease management systems for both health professionals and patients. In the SAPHIRE project, SRDC Team has extended the Guideline Interchange Format (GLIF) to bind the virtual data points to actual patient data sources, such as Hospital Information System data and real-time data coming from personal medical sensor devices, and hence to make it executable by computers; modelled state-of-the-art clinical guidelines for cardiovascular diseases in the extended GLIF format; and developed an agent based intelligent monitoring and decision support system that is able to provide real-time support to health professionals by executing the modelled clinical guideline definitions. SRDC has further improved this system, which is now known as Adaptive Care Planner Engine, in different disease domains by working together with several health professionals and experiencing with tens of patients in iCARDEA, EMPOWER and PALANTE projects for patients with Cardiovascular Implantable Electronic Devices (CIED), diabetes patients and arthritis patients. SRDC is also expert in achieving semantic interoperability in several domains including e-health and e-business. Recently in the SALUS project which is coordinated by SRDC, SRDC has developed a scalable semantic interoperability middleware integrating clinical care and clinical research domains, and on top of this middleware implemented several post market safety study tools such as case series characterisation and open-ended temporal pattern discovery to be used by safety analysts working at pharmacovigilance centres and pharmaceutical companies. SRDC has also been responsible for developing security and privacy mechanisms in many of R&D projects, including the ones mentioned above.