Work package 1 deals with the management of the project, both from the administrative and scientific perspectives. The main objectives are to liaise with the European Commission and put in place adequate consortium coordination and communication platform. Additionally, activities also include ensuring a quality assurance system and the management of ethical issues in the project with the support of the Ethical Committee.
• Coordination activities, project management
• Development and usage of a quality assurance system
• Consideration of ethical concerns in the project
Work package 2 focuses on the dissemination and exploitation of the project objectives, its phases of work, the activities themselves and the results.
One of its key objectives is to coordinate and support all of the consortium partners in disseminating information about the Project. This includes ensuring appropriate governance of the content of dissemination materials (such as author acknowledgements and approvals for the release interim or final foreground), tracking the progress of dissemination activities and maintaining records to include in annual dissemination report. A complementary objective is to ensure that the project reaches all relevant stakeholders with coordinated and reinforcing messages, through the most suitable channels.
This work package is also concerned with sustainable exploitation of the project results. In some cases, this will mean the adoption of its results by industry, for example through products that incorporate C3 Cloud interfaces or components. In other cases, this will mean the promotion of specific partner or multi partner results as commercial products or open source products.
Finally, this work package also needs to ensure that the health ICT industry is well prepared for the innovations that C3 Cloud will help to enable, which might have positive implications for the evolution of complimentary products and services that take advantage of better enabled person-centred care for patients with multiple conditions.
• Coordination of project dissemination and communication activities
• Identification of business and market opportunities, and providing exploitation plans
Work package was responsible for the design of the technical architecture of C3-Cloud. WP3 involved identification of relevant literature and state-of-the-art in the subject (Task 3.1), elicit, collate, categorise and document the requirements for the ICT part of C3-cloud with input from prospective users (Task 3.2), and finally construct a conceptual design for the C3-Cloud architecture (Task 3.3), which will be implemented by subsequent work packages. The outputs of WP3, in conjunction with those of WP7 will be used to create the various application modules for C3-Cloud. WP3 has produced and submitted all deliverables on time and according to the proposal’s specifications.
Current WP activities focus on Task 3.4, which is responsible with facilitating co-production in C3-Cloud, with its stakeholders. Following initial research and plans for co-production, Task 3.4 is at present documenting the co-production processes that has and will be taking place throughout the process.
WP4 is responsible of the Patient Pathway and Organisational Model Development & Change Management. The main objectıves of this WP are:
i. guidance for and development of new patient pathways and corresponding personalised care plans that can perform multi-morbid chronic disease management taking into account functional, social and psychosocial aspects, different professional perspectives and experience,
ii. development of adaptive organisational models for improved delivery of patient-centred integrated care that address the challenges posed by varying contexts and
iii. development of guidelines for smooth management of changes in models of care delivery, which are identified necessary for integrated care services.
During the first six months, the work of this WP has been addressed to the Task 4.2, Development of New Organisational Models for Improved Delivery of Integrated Care, according to DOA. The task 4.2. runs from month 1 to month 12. The partners have started the review and analyse of the existing organizational models in Europe and rest of the world. During this period Task 4.2 members have also worked on the development of a reliable tool to describe the organisational models.
WP6 is responsible of the Interoperability Middleware design and development. The provided solution must address technical, semantic and privacy/security interoperability challenges to seamlessly integrate with the existing health care, social care and home/community care information systems for enabling patient-centric interoperable care coordination in an informed manner with the involvement of all stakeholders. WP6 has three main objectives that are splitted in three tasks. All tasks have the same 10 months duration.
Task 6.1 has the objective to define FHIR C3-Cloud profiles and technical interoperability implementation guidelines, to develop open source toolkits (TIS) implementing the guidelines and the integration of the open source toolkits with pilot sites: OSAKI, RJH, SWFT
Task 6.2 has the objective to design a semantic interoperability platform that will enable common understanding of clinical data and resolve semantic mismatches due the use of different terminology systems between pilot sites and C3-Cloud top-level components
Task 6.3 has the objective to implement the security and privacy components that are common for all pilot sites and detailed analysis of the pilot site specific security and privacy systems
WP6 started in month 9 (1 January 2017) and has ended in month 18 (31 October 2017). All technical solutions for technical and semantic interoperability as well as security solutions have been developed. Specific interfaces have been also developed to provide demonstration of the activities of C3-Cloud the middleware layer. The three demonstrators have been described and documented in the finalized three deliverables of the period.
D6.1: C3-Cloud Technical Interoperability Implementation Guidelines and Open Source Toolkits (TIS). The main achievements were to set a data dictionary template to cover pilot sites data, to identify the set of FHIR C3-Cloud profiles relevant to the data dictionary and to set the toolkit for the integration with the patient data sources in C3-Cloud, including OSAKI, RJH and SWFT.
D6.2: Semantic Interoperability Platform (SIS). The main achievements were to design structural mappings from local formats to FHIR profiles to realize format conversion, to develop a semantic mapper based on a mappings resource (including dedicated C3-Cloud mappings) for the conversion of local value sets to terminology standards and for the update and management of the mappings resource itself. The semantic mapper is a web service that can be queried directly by other components or the C3-Cloud administrator.
D6.3: Privacy Protection and Security within the C3-Cloud Architecture (SPS). The main achievements were to agree on the concrete integration method with each pilot site taking into account their constraints and specific access control rules were defined, to integrate the SPS server with the C3-Cloud FHIR repository and to integrate the C3DP with the SPS Server.
The WP6 has successfully ended. Work in continuing in the context of the task 7.4 dealing with the Integration of all the technical components implemented in WP6 (TIS, SIS and SPS) before deployment at the pilot sites. Moreover, integration of SPS with the relevant security systems used at the pilot sites is an ongoing work within the scope of WP8.
WP7 is a complex work package with several important objectives to be achieved starting in month 5 and completing in month 26 of the overall C3-Cloud duration:
• Identification of the evidence based clinical guideline definitions and flowcharts for individual chronic conditions
• Implementation of several clinical decision support modules to be used by Personalised Care Plan Development Platform and the Coordinated Care and Cure Delivery Platform
• Development of the Personalised Care Plan Development Platform
• Development of the Coordinated Care and Cure Delivery Platform
• Integration of all the technical components implemented in WP5, WP6 and WP7 before deployment at the pilot sites
Workpackage 7 activities have been kick started to fulfill the first objective in the scope of Task 7.1. The core objective of Task 7.1 and its outcome D7.1 “Evidence Based Clinical Guideline Definitions and Flowcharts for Individual Chronic Conditions” is to present logical flowcharts for the clinical guidelines to be used in the project for the four diseases Diabetes, Heart Failure, Chronic Kidney Disease and Depression. The three pilot sites SWFT, OSAKI and RJH have identified the guideline documents that are currently in use in the three regions. The project partners decided to base the common work in C3-Cloud on the available guidelines from the English National Institute for Clinical Excellence (NICE) that are well-known and appreciated in the three countries as being well-researched. At Month 8, D7.1 has been finalized. Task 7.1 leader ORU and three pilot sites have studied NICE clinical guidelines in detail and developed in total 43 logical flowcharts that model the clinical recommendations from the NICE text documents. National deviations on top of the NICE recommendations have been identified and documented as well.
In addition to the guidelines based on the four diseases of C3-Cloud, the deliverable analyses the need for guidance supported by ICT relating to medication, which will also be implemented in C3-Cloud. Medication guidance relates to contraindications, interactions, registered hypersensitivity, special concerns for the elderly, and finally, the management of multi-morbidity.
Task 7.1 is a critical task within the overall work plan of C3-Cloud, and now the work continues in two main tracks in Task 4.1 for providing guidance on how individual clinical guidelines can be reconciled for the automation of personalised care plan development, and in Task 7.2 for implementation of Clinical Decision Support (CDS) Modules to be utilised in C3-Cloud Coordinated Care and Cure Delivery Platform.
Currently in Task 7.2, a detailed analysis is being carried out to identify the clinical requirements of the clinical decision support modules to de implemented in the light of D7.1. Meanwhile initial prototypes of CDS modules are being developed by implementing CDS-Hooks interfaces.
In parallel, Task 7.3 and Task 7.4 have been initialized to develop the Coordinated Care and Cure Delivery Platform (C3DP). A first complete care plan example ready to be used during prototype development has been finalized and modelled in HL7 FHIR. As the data repository of C3DP Platform, a FHIR Repository is being implemented in parallel with initial prototypes of the graphical interfaces of C3DP Platform enabling the display of existing care plan.
WP8 is responsible of the C3-Cloud Pilot application development and deployment in the real life settings. The main objectıves of this WP are:
i. the definition of the requirements and the detailed design of the C3-Cloud pilot application,
ii. to ensure data quality and readiness of the pilot sites before deployment and
iii. to manage the deployment and operation of the pilot application to real life settings.
During the first six month the work of this WP has been focused on the Task 8.1, Requirements and Use Cases of C3-Cloud Pilot Application, according to DOA. This task has run from month 1 to month 4.
Work Package 9 is responsible for the evaluation of the C3-Cloud components and pilot application. This is a complex undertaking due to the manifold aspects, clinical, technical and organisational that need to be taken into consideration.
The first 12 months of the project have therefore seen a concentration on planning and preparation. It is essential that this preparatory phase be undertaken thoroughly so that the evaluation methodology will be fit for purpose and the results as accurate and appropriate as possible. The objective addressed within this period was the defining of an approach that is able to predict and model the impact of the application when implemented at scale. In addition, criteria were defined with regard to subject selection, inclusion criteria, enrollment plans and ethical approval.